University of Oregon

Home

 

The Renal and Reproductive Physiology Lab is a NIH (HL114096, HL109843) and AHA (10SDG2600040) funded laboratory that studies a number of women’s health and fetal/child development issues. Our primary focus in on developing an better understanding of the mechanisms underlying the pathophysiology of the hypertension and fetal growth restriction associated with preeclamptic pregnancies. Currently funded projects include investigations into: 1) the role of exercise as a means to minimize the effects of placental ischemia on maternal cardiovascular function (PI); 2) the role of angiogenic factors in the regulation of cardiovascular and renal function during hypertension and pregnancy (PI); 3) the role of complement activation on angiogenic balance during pregnancy (Co-I with J Regal); 4) the role of angiogenic factors in fetal programming of disease (PI and co-I).

RECENT AWARDS

Congratulations to Kara Beasley for being awarded a 2014 APS Water and Electrolyte Homeostasis Section Research Distinction Award!

Congratulations to Haley Gillham for being awarded a 2014 Society for Experimental Biology and Medicine Young Investigator Award!

Congratulations to Sarah Macrorie who was awarded a 2014 APS Undergraduate Summer Research Fellowship!

Congratulations to Sarah Johnson who has been awarded a 2014 David S. Bruce Outstanding Undergraduate Abstract Award! This award provides $100 and a 2-year complimentary membership with The American Physiological Society to undergraduate students who are presenting their research at the Experimental Biology meeting. To be considered for the award, the candidate must be enrolled as an undergraduate student at the time of the abstract submission, be the first author on a submitted abstract for the EB meeting, and be working with an APS member. Selection of awardees is based on the abstract, letter of application, and letter of support from the research hostReceipt of the award is contingent upon presenting the research at EB.

Check out the Recent News link to find out about recent awards and presentations in the lab. The links for Lab members and Alumni have information about current and former lab members. The newsletter for the American Physiological Society Water and Electrolyte Section is here.

Interested in training opportunities in the Renal-Repro Lab? Click Here.

Recent Publications

Gilbert JS, Babcock SA, Regal RR, Regal JF. Of risks and ratios: the usefulness of angiogenic balance for diagnosing preeclampsia at different gestational ages. Hypertension. 2014 Feb;63(2):210-1. doi: 10.1161/HYPERTENSIONAHA.113.02050. Epub 2013 Oct 28. PubMed PMID: 24166754; PubMed Central PMCID: PMC3909769.

Lillegard KE, Johnson AC, Lojovich SJ, Bauer AJ, Marsh HC, Gilbert JS, Regal JF. Complement activation is critical for placental ischemia-induced hypertension in the rat. Mol Immunol. 2013 Nov;56(1-2):91-7. doi: 10.1016/j.molimm.2013.04.009. Epub 2013 May 15. PubMed PMID: 23685261; PubMed Central PMCID: PMC3687024.

Hocker AD, Boileau RM, Lantz BA, Jewett BA, Gilbert JS, Dreyer HC. Endoplasmic Reticulum Stress Activation during Total Knee Arthroplasty. Physiol Rep. 2013 Aug 1;1(3):e00052. PubMed PMID: 24159375; PubMed Central PMCID: PMC3804266.

Bauer AJ, Banek CT, Needham K, Gillham H, Capoccia S, Regal JF, Gilbert JS. Pravastatin attenuates hypertension, oxidative stress, and angiogenic imbalance in rat model of placental ischemia-induced hypertension. Hypertension. 2013 May;61(5):1103-10. doi: 10.1161/HYPERTENSIONAHA.111.00226. Epub 2013 Mar 4. PubMed PMID: 23460290; PubMed Central PMCID: PMC3909776.

Christopher T Banek, Ashley J Bauer, Karen M Needham, Hans C. Dreyer, and Jeffrey S Gilbert. AICAR (5-aminoimidazole-4-carboxamide-3-ribonucleoside) administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat. Am J Physiol Heart Circ Physiol; published ahead of print February 15, 2013, doi:10.1152/ajpheart.00903.2012

Jeffrey S. Gilbert, Christopher T. Banek, Sara A. Babcock & Hans C. Dreyer. Diabetes in Early Pregnancy: Getting to the Heart of the Matter. Diabetes January 2013 62:27-28

Jeffrey S. Gilbert, Christopher T. Banek, Ashley J. Bauer, Anne Gingery, and Karen Needham.  Exercise Training Attenuates Placental Ischemia-Induced Hypertension and Angiogenic Imbalance in the Rat. Hypertension 2012; first published on October 22 2012 asdoi:10.1161/HYPERTENSIONAHA.112.202275

Jeffrey S. Gilbert, Christopher T. Banek, Vern L. Katz, Sara A. Babcock, and Jean F. Regal. Complement Activation in Pregnancy: Too Much of a Good Thing? Hypertension 2012; first published on September 24 2012 asdoi:10.1161/HYPERTENSIONAHA.112.202747

Christopher T. Banek, Ashley J. Bauer, Anne Gingery, and Jeffrey S. Gilbert.  Timing of ischemic insult alters fetal growth trajectory, maternal angiogenic balance, and markers of renal oxidative stress in the pregnant rat. Am J Physiol Regul Integr Comp Physiol September 15, 2012 303:R658-R664; published ahead of print July 25, 2012, doi:10.1152/ajpregu.00250.2012